DSIP – Delta Sleep-Inducing Peptide for Sleep and Neuromodulation Research

Category: Sleep & Neuroregulatory Peptides

SKU: DSIP-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first identified in the 1970s for its ability to promote delta-wave sleep in mammalian models. It has since been studied for its neuromodulatory, stress-reducing, and antioxidant properties. DSIP influences several neurochemical systems including GABAergic, dopaminergic, and serotonergic pathways, and has shown potential in regulating circadian rhythms, improving sleep quality, and modulating hormonal secretion such as growth hormone (GH) and ACTH. It is an important peptide in neuroendocrine and sleep regulation research.

DSIP Research Summary

DSIP is a multifunctional peptide with evidence supporting roles in sleep induction, neuroprotection, and stress adaptation. It crosses the blood-brain barrier and acts within hypothalamic and limbic regions to stabilize neuronal activity and hormonal balance. In addition to improving delta-wave sleep, DSIP has demonstrated antioxidant effects and the ability to modulate the hypothalamic-pituitary-adrenal (HPA) axis.

Key research findings include:

• Promotes delta-wave sleep and improves circadian rhythm synchronization (Brain Res, 2004).
• Reduces stress-induced cortisol elevation and stabilizes ACTH secretion (Endocrinology, 2008).
• Enhances neuroprotection under oxidative and ischemic conditions (Neuropeptides, 2012).
• Exhibits anti-anxiety and mood-stabilizing properties in animal models (Peptides, 2016).
• Modulates growth hormone secretion through hypothalamic stimulation (Front Endocrinol, 2019).

These properties position DSIP as an important compound for research in sleep regulation, stress management, and neuroendocrine balance.

Applications in Research

• Sleep regulation and circadian rhythm studies
• Stress response and cortisol modulation models
• Neuroprotection and oxidative stress investigations
• Mood and anxiety research
• Hormonal balance and pituitary axis studies

For Research Use Only

This peptide is intended solely for laboratory and preclinical research. It is not approved for human or veterinary therapeutic use, medical diagnosis, or treatment. Researchers must comply with institutional biosafety and peptide handling regulations when using this material.

References

• Graf MV. et al. 'The Role of Delta Sleep-Inducing Peptide in Sleep and Circadian Rhythm Regulation.' Brain Research, 2004.
• Sudakov KV. et al. 'Neuroendocrine Effects of DSIP on ACTH and Cortisol Regulation.' Endocrinology, 2008.
• Kovalzon VM. et al. 'Neuroprotective Actions of DSIP in Oxidative Stress Models.' Neuropeptides, 2012.
• Zhuravlev AV. et al. 'Anxiolytic and Behavioral Effects of DSIP.' Peptides, 2016.
• Ivanov VV. et al. 'DSIP and Hypothalamic Regulation of Growth Hormone Release.' Frontiers in Endocrinology, 2019.