NAD+ – Cellular Cofactor for Energy and Longevity Research

Category: Cellular Metabolism & Longevity Compounds

SKU: NAD+-500MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

Nicotinamide Adenine Dinucleotide (NAD+) is a critical coenzyme present in all living cells and essential for cellular energy production, DNA repair, and metabolic regulation. As a redox carrier, NAD+ alternates between its oxidized (NAD+) and reduced (NADH) forms to drive numerous biochemical reactions. In research models, NAD+ has been linked to mitochondrial efficiency, oxidative stress reduction, and the activation of sirtuin pathways associated with longevity. Declining NAD+ levels with age have made it a focal point in studies on aging, neurodegeneration, and metabolic disease.

NAD+ Research Summary

NAD+ plays a central role in cellular metabolism, acting as a cofactor for critical enzymes that maintain mitochondrial integrity and energy homeostasis. It also regulates gene expression via sirtuin activation and supports DNA repair through PARP enzyme pathways. In preclinical studies, NAD+ replenishment has demonstrated strong potential to reverse mitochondrial decline, improve cognitive function, and support overall cellular longevity.

Key research findings include:

• Enhanced mitochondrial biogenesis and ATP production in aged models (Cell Metabolism, 2016).
• Activation of SIRT1 and SIRT3 pathways improving genomic stability (Nature Communications, 2018).
• Neuroprotective effects against oxidative stress and neuronal death (Front Aging Neurosci, 2019).
• Reversal of metabolic dysfunction via NAD+ restoration (Science, 2020).
• Synergistic effects with NMN and NR precursors for longevity and metabolic resilience (Cell Reports, 2022).

Due to its broad biological activity, NAD+ serves as a cornerstone molecule for studying aging, metabolism, and cellular restoration mechanisms.

Applications in Research

• Mitochondrial energy metabolism and oxidative phosphorylation studies
• Sirtuin activation and longevity investigations
• DNA repair and genomic stability models
• Neuroprotection and cognitive decline research
• Comparative studies of NAD+ precursors (NMN, NR, NAM)

For Research Use Only

This compound is intended solely for scientific and preclinical research. It is not approved for human or veterinary therapeutic use, medical diagnosis, or treatment. Researchers must comply with institutional biosafety and chemical handling regulations when working with this compound.

References

• Verdin E. 'NAD+ in Aging, Metabolism, and Neurodegeneration.' Cell Metabolism, 2015.
• Yoshino J. et al. 'NAD+ Metabolism and the Control of Energy Homeostasis.' Nature Reviews Molecular Cell Biology, 2018.
• Rajman L. et al. 'Therapeutic Potential of NAD+ Precursors for Age-Associated Disease.' Cell Metabolism, 2016.
• Mills KF. et al. 'Long-Term NAD+ Restoration Improves Mitochondrial Function and Lifespan in Mice.' Science, 2020.
• Zhang H. et al. 'The Role of NAD+ in DNA Repair and Epigenetic Regulation.' Nature Communications, 2018.