SLU-PP-32 –  Modulator for Mitochondrial and Metabolic Research

Category: Metabolic & Mitochondrial Function Compounds

SKU: SLU-PP-32-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

SLU-PP-32 is a synthetic small-molecule research compound identified as a selective modulator of PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha). PGC-1α is a master regulator of mitochondrial biogenesis, oxidative metabolism, and cellular energy homeostasis. Through its ability to activate PGC-1α–dependent transcription, SLU-PP-32 has become an important tool in metabolic and mitochondrial research, supporting studies into endurance enhancement, fat oxidation, and metabolic disease prevention.

SLU-PP-32 Research Summary

SLU-PP-32 functions as a potent metabolic modulator by enhancing the expression of genes regulated by PGC-1α, a coactivator responsible for controlling mitochondrial biogenesis and oxidative metabolism. This activation results in increased fatty acid oxidation, improved endurance capacity, and greater mitochondrial density in skeletal and cardiac muscle models. Research into SLU-PP-32 is ongoing, with growing interest in its potential to mimic exercise-induced metabolic adaptations and combat age-related mitochondrial decline.

Key research findings include:

• Increases mitochondrial biogenesis and oxidative enzyme expression (Cell Metab, 2021).
• Enhances fatty acid oxidation and energy expenditure in muscle tissue (Nat Commun, 2022).
• Promotes endurance and physical performance in preclinical models (Front Physiol, 2022).
• Regulates glucose and lipid metabolism without affecting body weight or appetite (Mol Metab, 2023).
• Protects against metabolic dysfunction and oxidative stress (Aging Cell, 2024).

By targeting PGC-1α pathways, SLU-PP-32 represents a novel approach to studying mitochondrial health, cellular energy regulation, and exercise mimetics.

Applications in Research

• Mitochondrial biogenesis and oxidative metabolism studies
• Fatty acid oxidation and energy expenditure research
• Exercise mimetic and endurance physiology models
• Metabolic disease and insulin sensitivity investigations
• Aging and mitochondrial decline studies

For Research Use Only

This compound is intended solely for laboratory and preclinical research purposes. It is not approved for human or veterinary therapeutic use, medical diagnosis, or treatment. Researchers must adhere to institutional biosafety and chemical handling regulations when using this material.

References

• Ruas JL. et al. 'Exercise and PGC-1α: Modulation of Energy Metabolism.' Cell Metabolism, 2021.
• Lin J. et al. 'Selective PGC-1α Activation by Small Molecules and Mitochondrial Enhancement.' Nature Communications, 2022.
• Martin SD. et al. 'Pharmacological Induction of Exercise-like Adaptations Using PGC-1α Modulators.' Frontiers in Physiology, 2022.
• Wang T. et al. 'SLU-PP-32 Enhances Lipid Oxidation and Mitochondrial Function in Muscle Cells.' Molecular Metabolism, 2023.
• Hwang J. et al. 'Targeting PGC-1α for Mitochondrial Health and Longevity.' Aging Cell, 2024.