MOTS-c 10MG 

Mitochondrial-Derived Peptide 

Category: Metabolic & Mitochondrial Function Peptides

MOTS-C-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, part of a family of mitochondrial-derived peptides (MDPs) that regulate cellular metabolism, energy balance, and stress response. It plays a critical role in mitochondrial-nuclear communication, enhancing insulin sensitivity, metabolic resilience, and muscle performance. Researchers utilize MOTS-c to study aging, metabolic disorders, exercise physiology, and cellular stress adaptation.

For laboratory research use only. Not approved for human or veterinary application.

MOTS-c Research Summary

Research into MOTS-c has revealed broad effects on metabolism, mitochondrial signaling, and cellular protection. As a metabolic modulator, it activates AMPK pathways, enhances glucose utilization, and mimics exercise-induced stress adaptation.

Key research findings include:

• Improved glucose tolerance and insulin sensitivity in high-fat diet models (Cell Metabolism, 2015).
• Exercise-induced expression increases up to 12-fold in skeletal muscle (Nature Communications, 2021).
• Decreased with age in plasma, suggesting potential relevance in longevity research (Aging-US, 2020).
• Reduces inflammation through MAPK and AHR/STAT3 signaling modulation (Frontiers in Physiology, 2023).

Collectively, MOTS-c serves as a unique research tool for studying mitochondrial-to-nuclear signaling, energy metabolism, and age-related decline.

Applications in Research

• Metabolic regulation and insulin sensitivity research
• Mitochondrial and nuclear cross-talk investigations
• Aging and exercise physiology models
• Bone metabolism and inflammatory pathway studies
• Comparative research with other mitochondrial-derived peptides (MDPs)

For Research Use Only

This compound is intended solely for laboratory research applications. It is not approved for human or veterinary use, medical diagnostics, or therapeutic applications. All users must follow institutional and regulatory biosafety protocols for handling and disposal.

References

• Lee C. et al. 'The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity.' Cell Metabolism, 2015.
• Wei W. et al. 'MOTS-c: Effects and Mechanisms Related to Stress, Metabolism, and Aging.' Journal of Translational Medicine, 2023.
• Cohen P. et al. 'Exercise-Induced MOTS-c Expression Enhances Muscle Metabolic Flexibility.' Nature Communications, 2021.
• Zhang L. et al. 'Mitochondrial Peptides and Aging-Associated Cellular Regulation.' Aging-US, 2020.
• Frontiers in Physiology. 'MOTS-c in Bone and Inflammation Research.' 2023.