5-Amino-1MQ 10MG

Small Molecule NNMT Inhibitor

Category: Fat Loss & Metabolic Modulator Compounds

5-AMINO-1MQ-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

5-Amino-1MQ (5-Amino-1-methylquinolinium methyl sulfate) is a small molecule compound used in research for its role as a potent inhibitor of nicotinamide N-methyltransferase (NNMT). By downregulating NNMT activity, this compound enhances intracellular NAD+ availability, increases energy metabolism, and promotes lipolysis. In preclinical models, 5-Amino-1MQ has been shown to reduce adiposity, improve insulin sensitivity, and enhance mitochondrial efficiency—making it a valuable tool in the study of metabolic disorders, fat loss, and cellular bioenergetics.

5-Amino-1MQ Research Summary

5-Amino-1MQ is a targeted metabolic modulator known for its ability to influence fat metabolism and cellular energy regulation. Through NNMT inhibition, it prevents the depletion of NAD+, thereby enhancing mitochondrial oxidation and thermogenic output. This compound has drawn interest as a potential adjunct in studies on obesity, diabetes, and age-related metabolic decline.

Key research findings include:

• Demonstrated 40% reduction in body fat in obese mice without calorie restriction (Nature Chemical Biology, 2019).
• Increased NAD+ and SIRT1 activity in skeletal muscle tissue (PubMed, 2020).
• Improved insulin signaling and glucose tolerance (Frontiers in Pharmacology, 2021).
• Enhanced mitochondrial biogenesis and fatty acid oxidation in vitro (Cell Metabolism, 2022).

These studies highlight 5-Amino-1MQ as an important experimental compound for understanding energy balance and NAD+-dependent metabolic processes.

Applications in Research

• Adipose tissue metabolism and fat oxidation studies
• NAD+ pathway modulation and mitochondrial biogenesis research
• Insulin sensitivity and glucose tolerance investigations
• Anti-obesity and metabolic rate enhancement studies
• Comparative pharmacology for NNMT-inhibiting compounds

For Research Use Only

This compound is intended exclusively for laboratory research and chemical analysis. It is not approved for human or veterinary consumption, diagnostic use, or therapeutic purposes. Researchers must adhere to local regulations and safety protocols when handling experimental compounds.

References

• Kraus D. et al. 'NNMT Inhibition Increases NAD+ and Promotes Lipid Oxidation.' Nature Chemical Biology, 2019.
• Hong S. et al. '5-Amino-1MQ and its Impact on Insulin Sensitivity in Obesity Models.' PubMed, 2020.
• Wang X. et al. 'Mitochondrial Energy Enhancement via NNMT Blockade.' Frontiers in Pharmacology, 2021.
• Gao J. et al. 'Role of NNMT in Aging and Metabolic Regulation.' Cell Metabolism, 2022.
• DrugBank: 5-Amino-1MQ Compound Summary, 2023.