KPV 10MG

Anti-Inflammatory α-MSH Fragment Peptide

Category: Anti-Inflammatory & Immunomodulatory Peptides

KPV-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

KPV (Lys-Pro-Val) is a tripeptide fragment derived from the C-terminal sequence of the naturally occurring neuropeptide α-Melanocyte-Stimulating Hormone (α-MSH). It has been widely studied in preclinical models for its potent anti-inflammatory and antimicrobial properties. Unlike corticosteroids or immunosuppressants, KPV exerts its effects through modulation of the NF-κB signaling pathway, reducing cytokine production without impairing healing. Researchers use KPV to explore inflammation control, gut barrier integrity, and immune regulation in epithelial and mucosal tissues.

KPV Research Summary

KPV has demonstrated significant anti-inflammatory and protective effects in preclinical models of inflammatory bowel disease, dermatitis, and wound repair. It is biologically active both as a topical and systemic research compound, showing efficacy in reducing TNF-α, IL-1β, and IL-6 levels while promoting epithelial healing and antimicrobial defense.

Key research findings include:

• Reduced intestinal inflammation and promoted epithelial regeneration in IBD models (Gut, 2010).
• Inhibited NF-κB activation and decreased cytokine release in keratinocytes (J Biol Chem, 2009).
• Demonstrated antimicrobial activity against gram-positive and gram-negative bacteria (Peptides, 2015).
• Accelerated wound healing and decreased oxidative damage in dermal models (Int J Mol Sci, 2019).

Because of its safety and anti-inflammatory profile, KPV is a valuable peptide for exploring non-steroidal modulation of inflammation, immune signaling, and epithelial recovery.

Applications in Research

• Inflammatory bowel disease (IBD) and mucosal repair models
• Dermatitis and skin barrier recovery studies
• Cytokine inhibition and immune response modulation research
• Antimicrobial peptide mechanism studies
• Oxidative stress and epithelial regeneration research

For Research Use Only

This peptide is intended exclusively for laboratory and preclinical research. It is not approved for human or veterinary use, therapeutic administration, or diagnostic testing. All handling should comply with institutional and regulatory safety standards.

References

• Getting SJ. et al. 'Anti-Inflammatory and Protective Role of α-MSH Peptide Fragments in Gut Inflammation.' Gut, 2010.
• Catania A. et al. 'KPV Inhibits NF-κB Activation and Cytokine Expression in Skin Cells.' Journal of Biological Chemistry, 2009.
• Cutuli M. et al. 'Antimicrobial and Anti-Inflammatory Properties of the Tripeptide KPV.' Peptides, 2015.
• Arunachalam M. et al. 'KPV Promotes Wound Healing and Reduces Oxidative Stress.' International Journal of Molecular Sciences, 2019.
• DrugBank: KPV Peptide – Mechanism and Research Applications, 2023.