Thymosin Alpha-1 – Immune-Modulating and Anti-Inflammatory Peptide for Immunotherapy Research

Category: Immune-Modulating & Cytokine-Regulating Peptides

SKU: TA1-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid peptide originally isolated from thymic tissue. It plays a critical role in the regulation of innate and adaptive immune responses by enhancing T-cell function and modulating cytokine activity. Tα1 has been studied extensively for its potential to restore immune balance in immunocompromised conditions, reduce inflammation, and improve host defense mechanisms. In research settings, it is used as an immunomodulatory agent to investigate antiviral responses, tumor immunology, and immune restoration after stress or infection.

Thymosin Alpha-1 Research Summary

Thymosin Alpha-1 has been widely studied for its immunoregulatory and antiviral effects. It functions as an immune modulator that enhances the body’s defense mechanisms by stimulating T-cell maturation, increasing natural killer (NK) cell activity, and promoting the production of Th1-type cytokines. Research has demonstrated its ability to restore immune competence in immunodeficient models, improve vaccine responses, and reduce inflammatory cytokine overactivation. Because of its selective modulation of immune signaling, Tα1 continues to be a key peptide for immunotherapy and inflammation research.

Key research findings include:

• Enhances T-cell differentiation and activation through thymic hormone pathways (Immunol Rev, 1981).
• Demonstrates antiviral effects via increased interferon and NK cell activity (J Biol Regul Homeost Agents, 1998).
• Reduces inflammatory cytokine production and restores immune balance (Clin Immunol, 2006).
• Improves immune recovery and vaccine response in immunocompromised models (Vaccine, 2012).
• Regulates immune checkpoint signaling in tumor microenvironments (Front Immunol, 2020).

Through its dual role in immune stimulation and regulation, Thymosin Alpha-1 provides a model compound for studying targeted immune enhancement and inflammation control in both infectious and autoimmune contexts.

Applications in Research

• T-cell activation and differentiation studies
• Cytokine modulation and immune signaling research
• Antiviral and immunodeficiency model investigations
• Tumor immunology and checkpoint regulation assays
• Inflammation and immune recovery studies

For Research Use Only

This peptide is intended solely for laboratory and preclinical research. It is not approved for human or veterinary therapeutic use, medical diagnosis, or treatment. Researchers must comply with institutional biosafety and peptide-handling regulations when using this compound.

References

• Goldstein AL. et al. 'The Role of Thymic Hormones in T-Cell Differentiation and Immunity.' Immunological Reviews, 1981.
• Romani L. et al. 'Thymosin Alpha-1 as an Immune Modulator in Viral and Fungal Infections.' Journal of Biological Regulators & Homeostatic Agents, 1998.
• Matteucci C. et al. 'Thymosin Alpha-1 and Cytokine Regulation in Inflammation.' Clinical Immunology, 2006.
• Garaci E. et al. 'Enhancement of Vaccine Responses by Thymosin Alpha-1 in Immunocompromised Models.' Vaccine, 2012.
• Pica F. et al. 'Thymosin Alpha-1 and Immune Checkpoint Modulation in Tumor Microenvironments.' Frontiers in Immunology, 2020.