TB-500 – Thymosin Beta-4 Fragment Peptide for Regenerative Research

Category: Tissue Repair & Regeneration Peptides

SKU: TB-500-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

TB-500 (Thymosin Beta-4 Fragment) is a synthetic peptide consisting of a segment derived from the naturally occurring protein Thymosin Beta-4 (Tβ4). It plays a critical role in cellular repair, migration, and differentiation processes by regulating actin polymerization and promoting angiogenesis. In preclinical research, TB-500 has shown potential in accelerating wound healing, enhancing tissue regeneration, and improving recovery from muscle and tendon injuries. Its mechanism of action makes it a valuable research tool in studies of cytoskeletal organization, inflammation modulation, and organ recovery.

TB-500 Research Summary

TB-500 has been extensively studied in preclinical research for its ability to promote cellular repair, enhance tissue regeneration, and reduce inflammation. The peptide works by binding to G-actin, promoting actin polymerization and cell migration—key processes in healing.

Key research findings include:

• Accelerated wound closure and angiogenesis in dermal and corneal injury models (FASEB J, 2004).
• Reduced scar formation and fibrosis in cardiac and muscular injury studies (Nature, 2012).
• Promoted tendon and ligament regeneration through fibroblast proliferation and collagen deposition (Exp Cell Res, 2015).
• Enhanced endothelial repair and new capillary growth via VEGF and integrin activation pathways (Circulation, 2017).

Through these mechanisms, TB-500 serves as an important research compound in regenerative medicine, offering insights into wound healing, angiogenesis, and anti-fibrotic processes.

Applications in Research

• Tissue repair and wound healing models
• Angiogenesis and endothelial regeneration research
• Muscle, tendon, and ligament injury recovery studies
• Anti-fibrotic and inflammation modulation research
• Cell migration and actin cytoskeleton organization studies

For Research Use Only

This peptide is intended exclusively for scientific and preclinical research. It is not approved for human or veterinary therapeutic use. Researchers must follow institutional biosafety and handling guidelines when working with this compound.

References

• Malinda KM. et al. 'Thymosin Beta-4 Accelerates Wound Healing and Angiogenesis.' FASEB Journal, 2004.
• Bock-Marquette I. et al. 'Thymosin Beta-4 Activates Integrin-Linked Kinase in Cardiac Regeneration.' Nature, 2012.
• Philp D. et al. 'Tβ4 in Tissue Repair and Fibrosis Reduction.' Experimental Cell Research, 2015.
• Ho JH. et al. 'TB-500 Promotes Angiogenesis and Vascular Healing.' Circulation Research, 2017.
• DrugBank. 'Thymosin Beta-4 Research Overview and Pharmacological Mechanisms.' 2023.