Semax – Synthetic Heptapeptide for Neuroprotection and Cognitive Research

Category: Nootropic & Neuroprotective Peptides

SKU: SEMAX-5MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) originally developed from the adrenocorticotropic hormone (ACTH) fragment ACTH(4–10). It has been widely studied for its neuroprotective, neurotrophic, and cognitive-enhancing properties. Semax influences the expression of neurotrophins such as BDNF (brain-derived neurotrophic factor), enhances dopaminergic and cholinergic neurotransmission, and protects neural tissue from oxidative and ischemic damage. It is a valuable peptide for research on neurodegenerative disease, learning, memory, and stress response.

Semax Research Summary

Semax has been extensively investigated in neurobiological and cognitive research for its ability to support brain function under stress, hypoxia, and oxidative conditions. Unlike traditional psychostimulants, it enhances cognitive performance without overstimulation or dependency risk. It has been shown to regulate gene expression related to neuroprotection, synaptic plasticity, and antioxidant defense.

Key research findings include:

• Increases BDNF and NGF expression in cortical neurons (Neurochem Res, 2010).
• Protects neurons from ischemic injury and oxidative stress (Brain Res, 2015).
• Enhances cognitive performance, attention, and memory retention in preclinical models (Behav Brain Res, 2016).
• Regulates neurotransmitter balance in dopamine and serotonin pathways (Front Pharmacol, 2019).
• Demonstrates antidepressant-like and anxiolytic effects via neurotrophic modulation (Mol Neurobiol, 2021).

These properties make Semax a leading research candidate in the field of neurodegenerative disease, traumatic brain injury, and cognitive enhancement studies.

Applications in Research

• Neuroprotection and ischemic injury models
• Cognitive performance and memory enhancement research
• Neurotrophin expression and plasticity regulation studies
• Depression, anxiety, and stress modulation models
• Neurodegenerative and traumatic brain injury research

For Research Use Only

This peptide is intended solely for laboratory and preclinical research. It is not approved for human or veterinary therapeutic use, medical diagnosis, or treatment. Researchers must follow institutional biosafety and peptide-handling guidelines when working with this compound.

References

• Ashmarin IP. et al. 'Semax: Neurotrophic and Neuroprotective Peptide Mechanisms.' Neurochemical Research, 2010.
• Andreeva LA. et al. 'Semax Protects Neurons Against Ischemic and Oxidative Injury.' Brain Research, 2015.
• Volkova AV. et al. 'Behavioral and Cognitive Effects of Semax in Stress and Learning Models.' Behavioral Brain Research, 2016.
• Kolosova NG. et al. 'Semax Modulates Neurotransmission and Reduces Oxidative Stress in Brain Aging.' Frontiers in Pharmacology, 2019.
• Gudasheva TA. et al. 'Semax in Neuropsychiatric Disorders and Neurogenesis Research.' Molecular Neurobiology, 2021.