SS-31 – Mitochondria-Targeted Peptide for Oxidative Stress Research

Category: Mitochondrial & Antioxidant Peptides

SKU: SS-31-10MG | Form: Lyophilized Powder | Purity: ≥ 99% (HPLC Tested)

For Research Use Only – Not for Human Consumption

Product Overview

SS-31 (Elamipretide) is a synthetic tetrapeptide engineered to selectively target the inner mitochondrial membrane, where it binds to cardiolipin and stabilizes mitochondrial structure and function. By mitigating mitochondrial reactive oxygen species (ROS) production and preventing oxidative damage, SS-31 supports research into mitochondrial dysfunction, aging, ischemia-reperfusion injury, and metabolic diseases. Its high cell permeability and potent antioxidative mechanism make it a valuable compound for exploring energy metabolism, apoptosis, and tissue resilience under oxidative stress.

SS-31 Research Summary

SS-31 is a mitochondria-targeted antioxidant peptide originally developed to prevent oxidative stress and preserve mitochondrial function. Its small, cationic, and aromatic structure enables it to penetrate cellular membranes and accumulate in the inner mitochondrial membrane. Once bound to cardiolipin, SS-31 enhances electron transport chain efficiency, reduces lipid peroxidation, and limits cytochrome c release.

Key research findings include:

• Decreased ROS production and improved ATP generation in cardiomyocytes (PNAS, 2010).
• Protected mitochondrial integrity during ischemia-reperfusion injury (Circulation Research, 2013).
• Attenuated neurodegeneration and improved cognitive performance in aging models (Nature Aging, 2021).
• Enhanced skeletal muscle function and reduced fatigue in mitochondrial myopathy studies (JCI Insight, 2018).

Through these mechanisms, SS-31 serves as a critical research tool for understanding mitochondrial bioenergetics, oxidative stress mitigation, and aging-related degenerative processes.

Applications in Research

• Mitochondrial dysfunction and oxidative stress models
• Neurodegenerative disease and aging research
• Cardioprotection and ischemia-reperfusion injury studies
• Skeletal muscle performance and fatigue investigations
• Comparative pharmacology of mitochondrial-targeted antioxidants

For Research Use Only

This compound is intended solely for scientific and laboratory research. It is not approved for human or veterinary therapeutic use. Researchers must follow appropriate institutional safety and handling protocols when working with this peptide.

References

• Szeto HH. 'Mitochondria-Targeted Peptides for Cardioprotection.' Circulation Research, 2013.
• Birk AV et al. 'The Mitochondrial-Targeted Peptide SS-31 Reduces Ischemia/Reperfusion Injury.' PNAS, 2010.
• Campbell MD et al. 'SS-31 Improves Skeletal Muscle Function in Mitochondrial Myopathy.' JCI Insight, 2018.
• Shi C. et al. 'SS-31 Preserves Mitochondrial Integrity and Cognitive Function During Aging.' Nature Aging, 2021.
• DrugBank: Elamipretide (SS-31) Mechanism and Pharmacology Summary, 2023.